Journal of Infection and Public Health
Volume 2, Issue 2 , Pages 86-90, 2009

Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt

  • Sarah Ahmed Abd El-kawy Shabayek

      Affiliations

    • El Kilo 4.5, The New University Buildings, Suez Canal University, Faculty of Pharmacy, Microbiology and Immunology Department, Ismailia 41522, Egypt
    • Corresponding Author InformationCorresponding author at: Tel.: +20 122712598/643917750; fax: +20 643230741.
    • ,
  • Salah Mohamed Abdalla

      Affiliations

    • El Kilo 4.5, The New University Buildings, Suez Canal University, Faculty of Pharmacy, Microbiology and Immunology Department, Ismailia 41522, Egypt
    • ,
  • Abouzeid M.H. Abouzeid

      Affiliations

    • Gynecology and Obstetrics Department, Ismailia General Hospital, Ismailia, Egypt

Received 3 February 2009; received in revised form 26 March 2009; accepted 30 March 2009.

Summary 

Group B Streptococcus (GBS) infection has long been recognized as a frequent cause of morbidity and mortality in newborn infants. The purpose of this study was to determine the colonization rate with GBS and the antibiotic susceptibility profile in pregnant women attending Gynecological clinics in Egypt. One-hundred and fifty vaginal swabs were collected from pregnant women at 35–40 weeks of gestation. In comparison to culture, direct latex agglutination testing revealed 100% sensitivity and 93.75% specificity. Thirty-eight specimens (25.3%) were found to be positive for GBS. Each isolate was tested for susceptibility to penicillin G, ampicillin, cefotaxime, erythromycin, clindamycin and vancomycin. Erythromycin-resistant isolates were further classified by double-disk method. All isolates were susceptible to penicillin G, ampicillin and vancomycin. Resistance to cefotaxime was detected in three isolates (7.89%). Five isolates (13.15%) were resistant to erythromycin and nine isolates (23.68%) were resistant to clindamycin. Four (80%) isolates had constitutive macrolide–lincosamide–StreptograminB resistance (cMLSBB) resistance and one (20%) isolate had inducible resistance (iMLSB) resistance. GBS colonization was found to be high in our region. Latex agglutination testing and Islam medium are reliable methods to detect GBS in late pregnancy; however, latex agglutination test is rapid and simpler. Penicillin G remains the first choice antibiotic for treatment of GBS infections.

Keywords: Group B Streptococcus, Pregnancy, GBS colonization, Antibiotic susceptibility, Constitutive resistance, Inducible resistance, Egypt

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PII: S1876-0341(09)00027-6

doi:10.1016/j.jiph.2009.03.004

Journal of Infection and Public Health
Volume 2, Issue 2 , Pages 86-90, 2009

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