Journal of Infection and Public Health
Volume 2, Issue 3 , Pages 129-135, 2009

Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Bahrain

  • Khalid Mubarak Bindayna

      Affiliations

    • Department of Microbiology, Immunology and Infectious Diseases, Arabian Gulf University, Manama, Bahrain
    • Department of Pathology, Microbiology Section, Salmaniya Medical Complex, Bahrain
    • Corresponding Author InformationCorresponding author at: Department of Microbiology, Immunology and Infectious Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 226671, Manama, Bahrain. Tel.: +973 39462466; fax: +973 17271090.
    • ,
  • Abiola C. Senok

      Affiliations

    • Department of Clinical Sciences, College of Medicine, University of Sharjah, United Arab Emirates
    • ,
  • Afaf E. Jamsheer

      Affiliations

    • Department of Pathology, Microbiology Section, Salmaniya Medical Complex, Bahrain

Received 19 March 2009; received in revised form 21 April 2009; accepted 28 April 2009.

Summary 

Objectives

To determine the occurrence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in Bahrain.

Methods

Retrospective analysis of records (January 2005–December 2006) at the Microbiology Laboratory of the Salmaniya Medical Complex, Bahrain which is the major national diagnostic laboratory.

Results

Out of a total of 11,886 member of family of Enterobacteriaceae isolated, 2695 (22.6%) were ESBL producers. Majority of ESBL isolates were from inpatients (n=2363; 87.7%). Escherichia coli (52.2%) and Klebsiella pneumoniae (24.3%) were predominant and distributed comparatively in the hospital wards while Proteus spp. (17.6%) was predominant in medical wards. Urine was the major source (52.2%) with low occurrence in blood cultures. No carbapenem resistant isolates was identified but resistance to three classes of antibiotics was exhibited by >25% of the isolated ESBL strains. Nitrofurantoin resistance was identified in 38.2% of urinary isolates.

Conclusion

This is the first report from Bahrain and it indicates that the prevalence of ESBL-producing isolates is high. Carbapenems were the most active drug against the ESBL-producing isolates. We recommend strict infection control to prevent trafficking into the community.

Keywords: ESBL, Bahrain

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PII: S1876-0341(09)00033-1

doi:10.1016/j.jiph.2009.04.005

Journal of Infection and Public Health
Volume 2, Issue 3 , Pages 129-135, 2009

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