Journal of Infection and Public Health
Volume 2, Issue 4 , Pages 204-208 , 2009

Frequency of Helicobacter pylori vacA genotypes in Iranian patients with gastric and duodenal ulcer

  • M.H. Salari

      Affiliations

    • Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Tel.: +98 21 6402640; fax: +98 21 6462267.
    • ,
  • M.H. Shirazi

      Affiliations

    • Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • M. Ahmmadi Hadaiti

      Affiliations

    • Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • N. Abrahimi Daryani

      Affiliations

    • Shariati Hospital, Tehran University of Medical Sciences, Iran

Received 15 March 2009 ,Revised 7 August 2009 ,Accepted 27 August 2009.

References 

  1. Warren JR, Marshall B. Unified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1:1273–1275
  2. Dampier W, Tozeren A. Signaling perturbations induced by invading H. pylori proteins in the host epithelial cells: a mathematical modeling approach. J Theor Biol. 2007;247:130–144
  3. Torres VJ, VanCompernolle SV, Sundrud MS. Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. J Immunol. 2007;179:5433–5440
  4. Ernst PB, Gold BD. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu Rev Microbiol. 2000;54:615–640
  5. Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover T. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. J Biol Chem. 1995;270:17771–17777
  6. Blaser MJ, Berg DE. Helicobacter pylori genetic diversity and risk of human disease. J Clin Investig. 2001;107:767–773
  7. Soltesz V, Zeeberg B, Wadstrom T. Optimal survival of Helicobacter pylori under various transport conditions. J Clin Microbiol. 1992;30:1453–1456
  8. Koehler CI, Mues MB, Dienes HP, Kriegsmann J, Modenthal PS. Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues. J Clin Pathol: Mol Pathol. 2003;56:36–42
  9. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, et al. CagA pathogenicity island of Helicobacter pylori, encodes type 1-specific and disease-associated virulence factors. Proc Natl Acad Sci USA. 1996;93:14648–14653
  10. Daniel A, Ingrid N, Yohannes M, Endale K, Senait A, Kiros A, et al. Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients. J Clin Microbiol. 2004;42(6):2682–2684
  11. Westblom TU, Madan E, Gudipati S, Midkiff BR, Czinn SJ. Diagnosis of Helicobacter pylori infection in adult and pediatric patients by using Pyloriset, a rapid latex agglutination test. J Clin Microbiol. 1992;30:96–98
  12. Ogata SK, Kawakami E, Patricio FR, Pedroso MZ, Santos AM. Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents. Sao Paulo Med J. 2001;119:67–71
  13. Queiroz DM, Mendes EN, Carvalho AS, Rocha GA, Oliveira AM, Soares TF, et al. Factors associated with Helicobacter pylori by a cagA-positive strain in children. J Infect Dis. 2000;181:626–630
  14. Rotimi O, Cairns A, Gray S, Moayyedi P, Dixon MF. Histological identification of Helicobacter pylori: comparison of staining methods. J Clin Pathol. 2000;53:756–759
  15. Vinette KM, Gibney KM, Proujansky R, Fawcett PT. Comparison of PCR and clinical laboratory tests for diagnosing H. pylori infection in pediatric patients. BMC Microbiol. 2002;40:3720–3728
  16. Gusmao VR, Mendes EN, Queiroz DM, Rocha GA, Rocha AMC, Ashour AAR, et al. VacA genotypes in Helicobacter pylori strains isolated from children with and without duodenal ulcer in Brazil. J Clin Microbiol. 2000;38:2853–2857
  17. Loeb M, Jayaratne P, Jones N, Sihoe A, Sherman P. Lack of correlation between vacuolating cytotoxin activity, cagA gene in Helicobacter pylori, and peptic ulcer disease in children. Eur J Clin Microbiol Infec Dis. 1998;17(2):653–656
  18. Gzyl A, Berg DE, Dzierzanowska D. Epidemiology of cagA/vacA genes in H. pylori isolated from children and adults in Poland. J Physiol Pharmacol. 1997;48:333–343
  19. Scholte GH, Van Doorn LJ, Quint WG, Linderman J. Genotyping of Helicobacter pylori strains in formalin-fixed or formaldehyde-sublimate-fixed paraffin-embedded gastric biopsy specimens. Diagn Mol Pathol. 2001;10:166–170
  20. Basso D, Navaglia F, Brigato L, Piva MG, Toma A, Greco E, et al. Analysis of Helicobacter pylori vacA and cagA genotypes and serum antibody profile in benign and malignant diseases. Gut. 1998;43:182–186
  21. Eurogast Study Group (1993). An international association between Helicobacter pylori infection and gastric cancer. Lancet. 1998;341:1359–1362
  22. Peek RM, Thompson SA, Donahue JP, Tham KT, Atherton JC, Blaser MJ, et al. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc Assoc Am Physicians. 1998;110:531–544
  23. Van Doorn L, Figueiredo C, Sanna R, Plaisier A, Schneeberger P, de Boer W, et al. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology. 1998;115:58–66
  24. Miehlke S, Thomas R, Guiterrez O, Graham DY, Go MF. DNA fingerprinting of single colonies of Helicobacter pylori from gastric cancer patients suggests infection with a single predominant strain. J Clin Microbiol. 1999;37:245–257
  25. Cover TL, Tummuru MKR, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem. 1994;269:10566–10573
  26. Wong BC, Yin Y, Berg DE, Xia HH, Zhang JZ, Wang WH, et al. Distribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong. Helicobacter. 2001;6:317–324
  27. Letley DP, Lastovica A, Louw JA, Hawkey CJ, Atherton JC. Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1 a genotype and natural occurrence of an s2/m1 allele. J Clin Microbiol. 1999;37:1203–1205
  28. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G. Molecular characterization of the 128kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA. 1993;90:5791–5795
  29. Yamaoka Y, Kodama T, Gutierrez O, Kim JG, Kashima K, Graham DY. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J Clin Microbiol. 1999;37:2274–2279
  30. Atherton J, Peek JR, Tham K, Cover T, Blaser M. Clinical and pathological importance of heterogeneity in vacA, the cytotoxin gene of Helicobacter pylori. Gastroenterology. 1997;112:92–95

PII: S1876-0341(09)00059-8

doi: 10.1016/j.jiph.2009.08.004

Journal of Infection and Public Health
Volume 2, Issue 4 , Pages 204-208 , 2009

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